An essential receptor for adeno-associated virus infection. Intracellular transport of recombinant adeno-associated virus vectors. This book chapter serves as an excellent general review on AAV capsid biology, function and structure and provides detailed descriptions for AAV purification and characterization studies. AAV capsid structure and cell interactions. AAV-8 and AAV-9 vectors cooperate with serum proteins differently than AAV-1 and AAV-6. Quantitative analysis of the packaging capacity of recombinant adeno-associated virus. The recombination signals for adeno-associated virus site-specific integration. A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes. A viral assembly factor promotes AAV2 capsid formation in the nucleolus.
Non-viral vectors for gene-based therapy. Viral vectors: a look back and ahead on gene transfer technology. Vannucci, L., Lai, M., Chiuppesi, F., Ceccherini-Nelli, L. State-of-the-art human gene therapy: part I. Emerging issues in AAV-mediated in vivo gene therapy. Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union. Nucleotide sequence and organization of the adeno-associated virus 2 genome. Cloning of infectious adeno-associated virus genomes in bacterial plasmids. Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Site-specific integration by adeno-associated virus. References 17 and 18 are the first reports to describe latent AAV genomes integrating into a specific region of human chromosome 19, which was later characterized and named AAVS1. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Organization of adeno-associated virus DNA in latently infected Detroit 6 cells. Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells. Detection of adeno-associated virus (AAV)-specific nucleotide sequences in DNA isolated from latently infected Detroit 6 cells. Adeno-associated virus RNA transcription in vivo.
Origin and termination of adeno-associated virus DNA replication. Extent of transcription of the viral genome in vivo. Adenovirus-associated virus multiplication. Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA.
Physical map and strand polarity of specific fragments of adenovirus-associated virus DNA produced by endonuclease R-EcoRI. Evidence for a single-stranded adenovirus-associated virus genome: formation of a DNA density hybrid on release of viral DNA. Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success-a personal perspective. My life with adeno-associated virus: a long time spent studying a short genome. Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective. Isolation of adenovirus-associated viruses from man. Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. This report is among the first to identify by electron microscopy the presence of AAV as a defective virus in simian AdV preparations. Adenovirus-associated defective virus particles.
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